著書・総説

Ohkubo T and Adachi H (2008) Leptin signaling and action in birds, Journal of Poultry Science 45: 233-240.

Shimada K, Ohkubo T, Saito N, Talbot RT and Sharp PJ (1993) The molecular biology of prolactin, In Avian Endocrinology (Ed. Sharp, P. J.), 135-148, Bristol, Journal of Endocrinology Ltd .

学術論文

Adachi H, Murase D and Ohkubo T (2013) Inhibitory mechanism of signal transduction through chicken leptin receptor by suppressor of cytokine signaling-3 (SOCS3). Journal of Poultry Science, 50: 262-269.

Adachi H, Murase, D, Atomura S and Ohkubo T (2012) Detection of leptin activity in living cells expressing chicken leptin receptor and STAT3. Journal of Poultry Science, 49: 46-50.

Murase D, Taniuchi S, Takeuchi S, Adachi H, Kansaku N, Okazaki K and Ohkubo T (2011) Role of chicken Pit-1 isoforms in activating growth hormone gene, General and Comparative Endocrinology, 173: 248-252.

高橋和裕、木村 信熙、田中実、大久保武 (2009) 黒毛和種における成長ホルモン受容体多型と枝肉形質の遺伝的な能力の比較、日本畜産学会報、80:429-435.

Kahn MSI, Ohkubo T, Masuda N, Tachibana T and Ueda H (2009) Central administration of metastin increases food intake through opioid neurons in chicks, Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology, 153: 209-212.

Adachi H, Takemoto Y, Bungo T and Ohkubo T (2008) Chicken leptin receptor is functional in activating JAK-STAT pathway in vitro. Journal of Endocrinology, 197: 335-342.

Ohkubo T, Nishio M, Tsurudome M, Ito M and Ito Y (2007) Existence of leptin receptor protein in chicken tissues: isolation of a monoclonal antibody against chicken leptin receptor. General and Comparative Endocrinology, 151: 269-273.

Kansaku N, Ohkubo T, Guémené D, Kuhnlein U and Zadworny D (2007) Molecular cloning of Pit-1 cDNA and genomic DNA of the domestic duck (Anas platyrhynchos). Animal Science Journal, 78: 180-188.

Ohkubo T, Shamoto K and Ogino T (2007) Structure and tissue distribution of cholecystokinin-1 receptor in chicken. Journal of Poultry Science, 44: 98-104.

Ohkubo T, Yano H, Takahashi S, Takahashi K, Kimura N and Tanaka M (2006) Bos indicus type of growth hormone receptor gene is retained in Japanese Black cattle. Journal of  Animal Breeding and Genetics, 617: 410-413.

Tachibana T, Tsukada A, Fujimoto M, Takahashi H, Ohkubo T, Boswell T and Furuse M (2005) Comparison of mammalian prolactin-releasing peptide and Carassius RFamide for feeding behavior and prolactin secretion in chicks, General and Comparative Endocrinology, 144: 264-269.

Kansaku N, Ohkubo T, Okabayashi H, Guémené D, Kuhnlein U, Zadworny D and Shimada K (2005) Cloning of duck PRL cDNA and genomic DNA, General and Comparative Endocrinology, 141:39-47.

Nakao N, Higashimoto Y, Ohkubo T, Yoshizato H, Nakai N, Nakashima K and Tanaka M (2004) Characterization of structure and expression of growth hormone receptor gene of Japanese flounder (Paralichtys olivaceus), Journal of Endocrinology, 182: 157-164.

Tachibana T, Saito S, Tomonaga S, Takagi T, Saito E, Nakanishi T, Koutoku T, Tsukada A, Ohkubo T, Boswell T and Furuse M (2004) Effect of central administration of prolactin-releasing peptide on feeding in chicks, Physiology & Behavior, 80: 713-719.

Ohkubo T, Tsukada A and Shamoto K (2003) cDNA cloning of chicken orexin receptor and tissue distribution: sexually dimorphic expression in chicken gonads, Journal of Molecular Endocrinology, 31: 499-508.

Phillips-Singh D, Li Q, Takeuchi, S, Ohkubo T, Sharp PJ and Boswell T (2003) Fasting differentially regulates expression of agouti-related peptide, pro-opiomelanocortin, prepro-orexin, and vasoactive intestinal polypeptide mRNAs in the hypothalamus of Japanese quail, Cell and Tissue Research, 313: 217-225.

Ohkubo T, Boswell T and Lumineau S (2002) Molecular cloning of chicken prepro-orexin cDNA and preferential expression in the chicken hypothalamus, Biochimica et Biophysica Acta, 1577: 476-480.

Ito M, Takebayashi S-I, Okumura K, Ohkubo T, Nishio M, Kawano M, Komada H, Ito Y and Tsurudome M (2002) Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1, International Journal of Biochemistry and Cell Biology, 34: 1152-1163.

Nishimura Y, Ohkubo T, Furuichi Y and Umekawa H (2002) Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization, Bioscience, Biotechnology and Biochemistry, 66: 2239-2242.

Higashimoto Y, Nakao N, Ohkubo T, Tanaka M and Nakashima K (2001) Structure and tissue distribution of prolactin receptor mRNA in Japanese flounder (Paralichtys olivaceus): conserved and preferential expression in osmoregulatory organs, General and Comparative Endocrinology 123: 170-179.

Kansaku N, Shimada K, Ohkubo T, Saito N, Suzuki T, Matsuda Y and Zadworny D (2001) Molecular cloning of chicken VIP receptor cDNA, tissue distribution and chromosomal localization, Biology of Reproduction 64: 1575-1581.

Tanaka M, Yamamoto I, Hayashida Y, Nakao N, Ohkubo T, Wakita M and Nakashima K (2000) Two novel first exons in the prolactin receptor gene are transcribed in a tissue-specific and sexual maturation-dependent manner to encode multiple 5’-truncated transcripts in the testis of the chicken, Biochimica et Biophysica Acta, 1491: 279-284.

Ohkubo T, Tanaka M and Nakashima K (2000) Molecular cloning of the chicken prolactin gene and activation by Pit-1 and cAMP-induced factor in GH3 cells, General and Comparative Endocrinology, 119: 208-216.

Ohkubo T, Tanaka M, Nakashima K (2000) Structure and tissue distribution of chicken leptin receptor (cOb-R) mRNA, Biochimica et Biophysica Acta, 1491: 303-308.

Tsukada A, Ohkubo T, Tanaka M, Nakashima K, Wakita M, and Hoshino S (1999) Effects of thyroid hormone on serum insulin like growth factor binding proteins (IGFBPs) and IGFBP-2 mRNA expression in chickens, Japanese Poultry Science, 36: 155-166.

Tanaka M, Yamamoto I, Ohkubo T, Wakita M, Hoshino S and Nakashima K (1999) cDNA cloning and developmental alterations in gene expression of the two Pit-1/GHF-1 transcription factors in the chicken pituitary, General and Comparative Endocrinology, 114: 441-448.

Tanaka M, Hoshino S, Nakashima K, Tsukada A, Ohkubo T and Wakita M (1998) Growth hormone receptor-dependent expression of IGFBP-4 mRNA in chicken liver, Growth Hormone & IGF Research, 8: 338-339.

Dunn IC, McEwan G, Okhubo T, Sharp PJ, Paton IR and Burt DW: Genetic mapping of the chicken prolactin receptor gene: a candidate gene for the control of broodiness, British Poultry Science, 39 (Suppl): S23-S24.

Tanaka M, Taniguchi T, Yamamoto I, Sakaguchi K, Yoshizato H, Ohkubo T and Nakashima K (1998) Gene and cDNA structures of flounder insulin-like growth factor-I (IGF-I): Multiple mRNA species encode a single short mature IGF-I, DNA and Cell Biology, 17: 859-868.

Sakaguchi K, Tanaka M, Ohkubo T, Yoshizato H, Hanai Y, Fujikawa T, Kaneko H and Nakashima K (1998) Tissue-specific regulation of growth hormone receptor and growth hormone binding protein gene expression during pregnancy and lactation in the rat, Endocrine Journal, 45 (Suppl): S105-S107.

Tsukada A, Ohkubo T, Sakaguchi K, Tanaka M, Nakashima K, Hayashida Y, Wakita M and Hoshino S (1998) Thyroid hormones are involved in insulin-like growth factor-I (IGF-I) production by stimulating hepatic growth hormone receptor (GHR) gene expression in the chicken, Growth Hormone & IGF Research, 8: 235-242.

Ohkubo T, Tsukada A, Tanaka M and Nakashima K (1998) Cloning and expression of pigeon growth hormone receptor cDNA in COS-7 monkey kidney cells, Comparative Biochemistry and Physiology, 120B: 449-455.

Ohkubo T, Tanaka M, Nakashima K and Sharp PJ (1998) Relationship between prolactin receptor mRNA in the anterior pituitary gland and hypothalamus and reproductive state in male and female bantams (Gallus domesticus), General and Comparative Endocrinology, 111: 167-176.

Tanaka M, Taniguchi T, Ohkubo T and Nakashima K (1998) cDNA cloning and characterization of neuron-specific enolase from chicken, Biochimica et Biophysica Acta, 1395: 28-33.

Ohkubo T, Tanaka M, Nakashima K, Talbot RT and Sharp PJ (1998) Prolactin receptor gene expression in the brain and peripheral tissues in broody and nonbroody breeds of domestic hen, General and Comparative Endocrinology, 109: 60-68.

Sudo S, Fujikawa T, Nagakura T, Ohkubo T, Sakaguchi K, Tanaka M, Nakashima K and Takahashi T (1997) Structures of mollusc shell framework proteins, Nature, 387: 563-564.

Kühn ER, Shimada K, Ohkubo T, Vleurick LM, Berghman LR and Darras VM (1996) Influence of recombinant chicken prolactin on thyroid hormone metabolism in the chick embryo, General and Comparative Endocrinology, 103: 349-358.

Sakaguchi K, Tanaka M, Ohkubo T, Doh-ura K, Fujikawa T, Sudo S and Nakashima K (1996) Induction of brain prolactin receptor long-form mRNA expression and maternal behavior in the pup-contacted male rats: promotion by prolactin administration and suppression by female contact, Neuroendocrinology, 63: 559-568.

Ohkubo T, Araki M, Tanaka M, Sudo S and Nakashima K (1996) Molecular cloning and characterization of yellowtail growth hormone gene and its promoter: a consensus sequence for teleost and avian Pit-1/GHF-1 binding sites, Journal of Molecular Endocrinology, 16: 63-72.

Tanaka M, Hayashida Y, Sakaguchi K, Ohkubo T, Wakita M, Hoshino S and Nakashima K (1996) Growth hormone-independent expression of insulin-like growth factor I messenger ribonucleic acid in extrahepatic tissues of the chicken, Endocrinology, 137: 30-34 (1996).

Tanaka M, Toma Y, Ohkubo T, Sudo S and Nakashima K (1995) Sequence of the flounder (Paralichthys olivaceus) growth hormone encoding gene and its promoter region, Gene, 165: 321-322.

Sakaguchi K, Ohkubo T, Sugiyama T, Tanaka M, Ushiro T and Nakashima K (1994) Differential regulation of prolactin receptor mRNA expression in rat liver and kidney by testosterone and oestradiol, Journal of Endocrinology, 143: 383-392.

Ohkubo T, Tanaka M, Nakashima K, Shimada K, Saito N and Sato K (1993) High-level expression of biologically active chicken prolactin in E. coli., Comparative Biochemistry and Physiology, 105A: 123-128.

Tanaka M, Maeda K, Okubo T and Nakashima K (1992) Double antenna structure of chicken prolactin receptor deduced from the cDNA sequence, Biochemical and Biophysical Research Communications, 188: 490-496.

Kuwayama T, Shimada K, Saito N, Ohkubo T, Sato K, Wada M and Ichinoe K (1992) Effects of removal of chicks from hens on concentrations of prolactin, lutenizing hormone and oestradiol in plasma of brooding gifujidori hens, Journal of Reproduction and Fertility, 95: 617-622.